Platform
Our Technology
First in class
Input: Mixed biological sample
Output: Nucleic acids & proteins
EVoE Cartridge
The EVoE System is based on the ExoTIC technology, developed by Prof. Utkan Demirci’s lab at Stanford University. The EVoE System partitions biologically complex samples into an EVs fraction, and a secondary fraction enriched with nucleic acids and soluble proteins. The EVoE consumable uses a simple but powerful technology based on a nanofiltration chamber. The EVoE System is fully automated and generates highly pure EVs at the highest possible yields
Publications
The exosome total isolation chip
​Liu F, Vermesh O, Mani V, Ge TJ, Madsen SJ, Sabour A, et al. The exosome total isolation chip. ACS Nano. 2017;11:10712–10723. doi:10.1021/acsnano.7b04878
​Atlas of exosomal microRNAs secreted from human iPSC-derived cardiac cell types
Chandy M, Rhee JW, Ozen MO, Williams DR, Pepic L, Liu C, et al. Atlas of exosomal microRNAs secreted from human iPSC-derived cardiac cell types. Circulation. 2020;142:1794–1796. doi:10.1161/CIRCULATIONAHA.120.048364
​Mitochondria-rich extracellular vesicles rescue patient-specific cardiomyocytes from doxorubicin injury: insights into the SENECA trial
​O’Brien CG, Ozen MO, Ikeda G, Vaskova E, Jung JH, Bayardo N, et al. Mitochondria-rich extracellular vesicles rescue patient-specific cardiomyocytes from doxorubicin injury: insights into the SENECA trial. JACC CardioOncol. 2021;3:428–440. doi:10.1016/j.jaccao.2021.05.006
Label-free identification of exosomes using Raman spectroscopy and machine learning
Parlatan U, Ozen MO, Kecoglu I, Koyuncu B, Torun H, Khalafkhany D, et al. Label-free identification of exosomes using Raman spectroscopy and machine learning. Small. 2023;19:2205519. doi:10.1002/smll.202205519